微粒体环氧乙烯合成酶：化学致癌物对其动力学参数的修饰
Microsomal vinyl oxide synthetase: modification of its kinetic parameters by chemical carcinogens.
作者信息
Malvoisin E, Roberfroid M, Mercier M
出版信息
Arch Toxicol Suppl. 1979(2):465-9. doi: 10.1007/978-3-642-67265-1_58.
PMID:288361
Abstract
The kinetic parameters of liver microsomal vinyl oxide synthetase as well as their modifications under the influence of various pretreatments have been evaluated, using 1,1,2-trichlorethylene (TCE) as a substrate. The results were correlated with those obtained using aldrin oxide synthetase and benzpyrene hydroxylase as typical cytochrome P-450 dependent enzymatic activity. The treatments of animals with chemical carcinogens selectively increase the affinity of those enzymes for their substrates.
摘要
以1,1,2-三氯乙烯（TCE）为底物，评估了肝微粒体环氧乙烯合成酶的动力学参数及其在各种预处理影响下的变化。将结果与使用氧化艾氏剂合成酶和苯并芘羟化酶作为典型的细胞色素P-450依赖性酶活性所获得的结果进行了关联。用化学致癌物处理动物会选择性地增加这些酶对其底物的亲和力。
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