Nabai Layla, Ghahary Aziz
Burn and Wound Healing Laboratory, Department of Surgery, Division of Plastic Surgery, University of British Columbia, Vancouver, BC, Canada.
Methods Mol Biol. 2017;1627:81-89. doi: 10.1007/978-1-4939-7113-8_6.
Excessive fibrous tissue deposition after injury in the form of hypertrophic scar remains a major clinical challenge. The development of an animal model for such scarring has been extremely difficult because of a major difference between the healing process in laboratory animals and humans. Here, we describe the rabbit ear model for excessive dermal scarring which has some clinical and histological resemblance to human hypertrophic scar. Since its development, this model has been widely used to study the cellular and molecular biology of hypertrophic scarring and evaluate the efficacy of new therapeutic agents.
损伤后以增生性瘢痕形式出现的过度纤维组织沉积仍然是一个重大的临床挑战。由于实验动物和人类的愈合过程存在重大差异，因此开发用于此类瘢痕形成的动物模型极其困难。在此，我们描述了一种用于过度皮肤瘢痕形成的兔耳模型，该模型在临床和组织学上与人类增生性瘢痕有一些相似之处。自该模型开发以来，已被广泛用于研究增生性瘢痕形成的细胞和分子生物学，并评估新治疗药物的疗效。
