中国北京城区引起侵袭性感染的酵母分离株的流行病学及抗真菌药敏情况
Epidemiology and antifungal susceptibilities of yeast isolates causing invasive infections across urban Beijing, China.
作者信息
Guo Li-Na, Xiao Meng, Cao Bin, Qu Fen, Zhan Yu-Liang, Hu Yun-Jian, Wang Xin-Ru, Liang Guo-Wei, Gu Hai-Tong, Qi Jun, Yuan Hui, Min Rong, Wang Fei-Yan, Liu Lin-Juan, Wang Hai-Bin, Jiang Wei, Duan Xue-Guang, Xu Wen-Jian, Yu Yan-Hua, Su Jian-Rong, Zhang Jian-Zhong, Nong Jin-Qing, Liu Shu-Mei, Li Jun, Liu Jun-Ting, Yue Zhi-Gang, Yang Duo, Guo Jie, Zhao Rui, Zhang Ya-Nan, Yang Xi-Ming, Liu Xiao-Qing, Hsueh Po-Ren, Xu Ying-Chun
机构信息
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Department of Clinical Laboratory, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100000, China.
出版信息
Future Microbiol. 2017 Sep;12:1075-1086. doi: 10.2217/fmb-2017-0036. Epub 2017 Aug 24.
AIM
To investigate the species distribution and antifungal susceptibility profiles of yeast isolates causing invasive infections across Beijing.
MATERIALS & METHODS: A total of 1201 yeast isolates recovered from blood and other sterile body fluids were correctly identified by matrix-assisted laser desorption/ionization TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed according to the Clinical and Laboratory Standards Institute broth microdilution method.
RESULTS
Candida (95.5%) remained the most common yeast species isolated; Candida albicans (38.8%) and Candida parapsilosis (22.6%) were the leading species of candidemia. Azole resistances were mainly observed in Candida glabrata and Candida tropicalis isolates.
CONCLUSION
This study outlined the epidemiologic data of invasive yeast infections and highlighted the need for continuous monitoring of azole resistances among C. glabrata and C. tropicalis isolates in Beijing.
目的
调查北京地区引起侵袭性感染的酵母分离株的菌种分布及抗真菌药敏谱。
材料与方法
从血液和其他无菌体液中分离出的1201株酵母分离株，通过基质辅助激光解吸/电离飞行时间质谱并辅以DNA测序进行正确鉴定。根据临床和实验室标准协会肉汤微量稀释法进行抗真菌药敏试验。
结果
念珠菌（95.5%）仍然是最常见的分离酵母菌种；白色念珠菌（38.8%）和近平滑念珠菌（22.6%）是念珠菌血症的主要菌种。唑类耐药主要见于光滑念珠菌和热带念珠菌分离株。
结论
本研究概述了侵袭性酵母感染的流行病学数据，并强调需要持续监测北京地区光滑念珠菌和热带念珠菌分离株中的唑类耐药情况。
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