Saito R, Fujiwara M, Kamiya H, Ono N
Pharmacol Biochem Behav. 1987 Mar;26(3):543-6. doi: 10.1016/0091-3057(87)90163-8.
The effects of several neurotransmitters on prostaglandin (PG) D2-induced cataleptic behavior in rats were investigated by the high bar test. Intracerebroventricular administration of PG D2 elicited cataleptic behavior in a dose-dependent manner without producing a marked change in spontaneous motor activity. The incidences of cataleptic behavior were 20% and 100% at doses of 2 nmol and 50 nmol of PG D2, respectively. Intraperitoneal pretreatment with L-DOPA (100 mg/kg), apomorphine (1 mg/kg), amantadine (0.2 mg/kg), atropine (0.5 mg/kg) or p-chlorophenylalanine (300 mg/kg) significantly decreased the cataleptic behavior induced by 50 nmol of PG D2. Conversely, simultaneous treatment with 5-hydroxy-L-tryptophan (30 mg/kg), 5-methoxy-N,N-dimethyltryptamine (5 mg/kg), imipramine (20 mg/kg) or clomipramine (10 mg/kg) markedly increased the cataleptic behavior induced by 2 nmol of PG D2. Propranolol (10 mg/kg) and phenoxybenzamine (10 mg/kg) did not affect the induction of cataleptic behavior by either 2 nmol or 50 nmol of PG D2. These results suggest that PG D2 might be involved in inducing cataleptic behavior by modulating serotonergic, cholinergic and dopaminergic systems.
通过高杠试验研究了几种神经递质对前列腺素（PG）D2诱导的大鼠僵住行为的影响。脑室内注射PG D2以剂量依赖的方式引发僵住行为，而不会使自发运动活动产生明显变化。PG D2剂量为2 nmol和50 nmol时，僵住行为的发生率分别为20%和100%。用左旋多巴（100 mg/kg）、阿扑吗啡（1 mg/kg）、金刚烷胺（0.2 mg/kg）、阿托品（0.5 mg/kg）或对氯苯丙氨酸（300 mg/kg）进行腹腔预处理，可显著降低由50 nmol PG D2诱导的僵住行为。相反，同时用5-羟色氨酸（30 mg/kg）、5-甲氧基-N，N-二甲基色胺（5 mg/kg）、丙咪嗪（20 mg/kg）或氯米帕明（10 mg/kg）处理，可显著增加由2 nmol PG D2诱导的僵住行为。普萘洛尔（10 mg/kg）和酚苄明（10 mg/kg）对2 nmol或50 nmol PG D2诱导的僵住行为均无影响。这些结果表明，PG D2可能通过调节血清素能、胆碱能和多巴胺能系统参与诱导僵住行为。
