前列腺素D2诱导大鼠僵住症：5-羟色胺的作用

Prostaglandin D2-induced catalepsy in rats: role of 5-hydroxytryptamine.

作者信息

Bhattacharya S K, Rao P J

机构信息

Department of Pharmacology, Banaras Hindu University, Varanasi, India.

出版信息

J Pharm Pharmacol. 1987 Sep;39(9):743-5. doi: 10.1111/j.2042-7158.1987.tb06983.x.

DOI:10.1111/j.2042-7158.1987.tb06983.x

PMID:2890744

Abstract

Prostaglandin D2 (PGD2), the major PG in the rat brain, induced a dose-related catalepsy in rats on intracerebroventricular (i.c.v.) administration. This cataleptic response was significantly attenuated following the i.c.v. administration of pharmacological agents that decrease rat brain 5-hydroxytryptamine (5-HT) activity. PGE1 synergized but PGF2 alpha antagonized the catalepsy induced by PGD2. PGD2 and PGE1 have previously been shown to augment rat brain 5-HT activity, whereas PGF alpha inhibited it. It is therefore likely that the observed effects of these PGs on catalepsy involve a central 5-HT mechanism.

摘要

前列腺素D2（PGD2）是大鼠脑中主要的前列腺素，脑室内（i.c.v.）给药时可在大鼠中诱导剂量相关的僵住症。在脑室内给予降低大鼠脑5-羟色胺（5-HT）活性的药物后，这种僵住症反应显著减弱。PGE1具有协同作用，而PGF2α则拮抗PGD2诱导的僵住症。先前已表明PGD2和PGE1可增强大鼠脑5-HT活性，而PGFα则抑制该活性。因此，这些前列腺素对僵住症的观察到的作用可能涉及中枢5-HT机制。