Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
J Dermatol. 2018 Mar;45(3):322-325. doi: 10.1111/1346-8138.14009. Epub 2017 Aug 24.
Interleukin (IL)-33 can function both as a conventional cytokine and as a nuclear factor regulating gene transcription. IL-33 expression is strongly upregulated in the nucleus of keratinocytes and serum of patients with psoriasis. However, the role of IL-33 in psoriasis is unclear, and IL-33 expression in the lesional psoriatic skin after conventional systemic treatments has not been investigated. In this study, we aimed to compare IL-33 mRNA in patients' lesional skin samples and IL-33 protein expression in patients' serum before and after treatment with methotrexate (MTX) and narrowband ultraviolet B (NB-UVB). IL-33 mRNA levels in lesional skin and IL-33 protein levels in serum were downregulated after treatment with MTX. Results revealed a significant decrease in IL-33 protein expression (P = 0.028). IL-33 expression increased after NB-UVB treatment. IL-33 production is associated with inflammatory skin in psoriasis, possibly through its cytokine function. However, high expression of IL-33 after NB-UVB treatment suggests the occurrence of unknown functions to alleviate psoriatic lesions without IL-33 involvement.
白细胞介素 (IL)-33 既能作为传统细胞因子发挥作用，也能作为核因子调节基因转录。银屑病患者的角质形成细胞核和血清中，IL-33 的表达明显上调。然而，IL-33 在银屑病中的作用尚不清楚，也尚未研究过常规系统治疗后银屑病皮损中 IL-33 的表达。在这项研究中，我们旨在比较甲氨蝶呤 (MTX) 和窄谱中波紫外线 (NB-UVB) 治疗前后患者皮损样本中的 IL-33mRNA 和患者血清中的 IL-33 蛋白表达。MTX 治疗后，皮损皮肤中的 IL-33mRNA 水平和血清中的 IL-33 蛋白水平下调。结果显示 IL-33 蛋白表达显著下降（P=0.028）。NB-UVB 治疗后 IL-33 表达增加。IL-33 的产生与银屑病的炎症性皮肤有关，可能通过其细胞因子功能。然而，NB-UVB 治疗后 IL-33 的高表达表明，在不涉及 IL-33 的情况下，可能会发生未知的功能来缓解银屑病皮损。
