Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
National Research Council of Italy (CNR), Institute of Biological Resources and Marine Biotechnologies (IRBIM), Messina, Italy.
Mediators Inflamm. 2019 Oct 14;2019:7158014. doi: 10.1155/2019/7158014. eCollection 2019.
IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies. It acts as an alarmin, released by damaged cells. Binding to a ST2 receptor, it stimulates many immune cells such as ILC2 and Th2 cells. IL-33/ST2 axis seems to be involved in Th17 response. According to this, a review was performed to analyze if IL-33 even interplay in the onset of psoriasis, a Th1/Th17 inflammatory disease.
Data obtained from the included articles are study author name, publication date, group studied, clinical and biological variables, laboratory tests, and outcome of interest of the study.
Data are obtained from the 19 studies identified, which assessed the association between IL-33 and psoriasis.
It seems to promote the innate-adaptive immune crosstalk: it could induce mast cells and neutrophil response after being released by injured keratinocytes and after stimulation by some cytokines, in particular TNF, INF, and IL-17A. In addition, it seems to be involved from the onset of disease to the development of comorbidities, as psoriatic arthritis.
The core of the future research on psoriasis could be to fully understand the role of this complex cytokine, in order also to find a new therapeutic approach.
IL-33 属于 IL-1 家族，在多种生物学过程以及包括皮肤疾病在内的不同疾病的发病机制中发挥作用。它作为一种警报素，由受损细胞释放。与 ST2 受体结合，它刺激多种免疫细胞，如 ILC2 和 Th2 细胞。IL-33/ST2 轴似乎参与 Th17 反应。基于此，我们进行了一项综述，以分析 IL-33 是否在银屑病（一种 Th1/Th17 炎症性疾病）的发病中起作用。
从纳入的文章中获取的数据是研究作者姓名、发表日期、研究组、临床和生物学变量、实验室检查以及研究的关注结果。
从评估 IL-33 与银屑病之间关联的 19 项研究中获得了数据。
它似乎促进了先天适应性免疫的相互作用：在受损角质形成细胞释放后，以及在某些细胞因子（特别是 TNF、IFN 和 IL-17A）的刺激下，它可以诱导肥大细胞和中性粒细胞反应。此外，它似乎从疾病发作到并发症的发展（如银屑病关节炎）都有涉及。
未来对银屑病的研究重点可能是充分了解这种复杂细胞因子的作用，以便找到新的治疗方法。
