Berling Ingrid, Gupta Rahul, Bjorksten Cecilia, Prior Felicity, Whyte Ian M, Berry Sherman
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, NSW, and; Discipline of Clinical Pharmacology, University of Newcastle, NSW, and; Faculty of Health and Medicine, University of Newcastle, NSW, Australia.
Hunter New England Mental Health Service, Newcastle, NSW, and; Faculty of Health and Medicine, University of Newcastle, NSW, Australia.
Australas Psychiatry. 2018 Feb;26(1):50-55. doi: 10.1177/1039856217726212. Epub 2017 Aug 24.
There is an increased rate of sudden cardiac death (SCD) in mental health patients. Some antipsychotic medications are known to prolong the QT interval, thus increasing a patient's risk of SCD via the arrhythmia, torsades de pointes (TdP). Our aim was to evaluate assessment for QT prolongation within a public inpatient mental health facility by auditing electrocardiograph (ECG) use.
We reviewed records of all mental health inpatient admissions to a public emergency mental health inpatient unit between 1 January 2016 and 11 February 2016. ECG availability was noted and QT interval was manually measured and assessed for risk of TdP using the QT nomogram when present. Demographic information and medication use was collected.
Of 263 mental health inpatient admissions, 50 (19%) presentations had an ECG. A total of four (8%) had a prolonged QT interval. Of the 50 patients with an ECG, 12 (24%) were taking medication known to prolong the QT interval.
There was very limited risk assessment for QT prolongation in a public hospital psychiatric inpatient unit, with less than 20% of patients having an ECG performed. Our study supports an association between QT-prolonging drugs and a clinically significant prolonged QT interval; however, a larger study with routine ECG screening is required.
精神疾病患者的心源性猝死(SCD)发生率有所增加。已知某些抗精神病药物会延长QT间期,从而通过心律失常——尖端扭转型室速(TdP)增加患者发生SCD的风险。我们的目的是通过审核心电图(ECG)的使用情况,评估一家公立住院精神卫生机构对QT间期延长的评估情况。
我们回顾了2016年1月1日至2016年2月11日期间,一家公立紧急精神卫生住院单元所有精神科住院患者的记录。记录ECG的可用性,并手动测量QT间期,如有则使用QT列线图评估TdP风险。收集人口统计学信息和用药情况。
在263例精神科住院患者中,50例(19%)进行了ECG检查。共有4例(8%)QT间期延长。在进行ECG检查的50例患者中,12例(24%)正在服用已知会延长QT间期的药物。
在一家公立医院的精神科住院单元,对QT间期延长的风险评估非常有限,不到20%的患者进行了ECG检查。我们的研究支持延长QT间期的药物与临床上显著的QT间期延长之间存在关联;然而,需要进行一项更大规模的常规ECG筛查研究。