Institute for Pharmaceutical and Medicinal Chemistry, Westfälische Wilhelms-Universität , Münster, Germany .
J Med Food. 2018 Jan;21(1):1-4. doi: 10.1089/jmf.2017.0015. Epub 2017 Aug 24.
This review summarizes the effects of the standardized proprietary bark extract of the French maritime pine (Pycnogenol) in mild osteoarthritis (OA), stage 1 and 2. The extract exerts antioxidative, anti-inflammatory, and chondroprotective effects in vitro and in vivo. Its phenolic acids as well as catechin and taxifolin are quickly absorbed. Active metabolites, produced by gut microbiota in the intestinal tract from oligomeric procyanidins, appear in blood 6 h following ingestion and remain for at least 14 h, providing a long-lasting flow of anti-inflammatory substances for relief of OA symptoms. These constituents of Pycnogenol could be detected in serum, blood cells, and synovial fluid of OA patients. The resulting inhibition of cartilage-destructing proteases and pain-producing cyclo-oxygenases provides the basis for relief from pain, improvement of stiffness, enhanced mobility, and well-being in three clinical studies with the pine bark extract as an adjunct supplement. Sparing the use of nonsteroidal anti-inflammatory drugs, supplementation with the pine bark extract reduced gastric complications and hospital admissions of OA patients. Because of its favorable safety profile and sustained anti-inflammatory action, Pycnogenol represents an option as an add-on supplement for OA patients.
本文综述了法国沿海松树（碧萝芷）标准化专有树皮提取物在轻度骨关节炎（OA）、1 期和 2 期的作用。该提取物在体外和体内具有抗氧化、抗炎和软骨保护作用。其酚酸以及儿茶素和松脂醇可被迅速吸收。肠道微生物群在肠道中从低聚原花青素产生的活性代谢物，在摄入后 6 小时出现在血液中，并至少持续 14 小时，为缓解 OA 症状提供了持久的抗炎物质流。这些碧萝芷的成分可以在 OA 患者的血清、血细胞和滑液中检测到。由此抑制软骨破坏蛋白酶和产生疼痛的环氧化酶，为缓解疼痛、改善僵硬、增强活动能力和提高舒适度提供了基础，这在三项临床研究中得到了证实，其中松树皮提取物作为辅助补充剂。由于其良好的安全性和持续的抗炎作用，碧萝芷可作为 OA 患者的附加补充剂。
