Wiedmeier S E, Burnham D K, Singh U, Daynes R A
Thymus. 1987;9(1):25-44.
The object of this investigation was to establish whether the intracameral implantation of thymic epithelial grafts could be utilized as a valid in vivo experimental model for probing the possible mechanisms whereby the sympathetic innervation of the thymus influences thymocyte dynamics. Our findings suggest that deoxyguanosine-treated thymic epithelial grafts, implanted into the anterior chamber of the eye, were receptive to host lymphoid progenitor cells, capable of supporting T-lymphocyte maturational processes, and were able to export mature T cells to the secondary lymphoid organs of a previously T-cell deficient host. In addition, we verified that the number of lymphoid cells recovered from a thymic epithelial graft which had been implanted into an anterior chamber devoid of sympathetic nerve input was generally greater than the number of lymphoid cells recovered from a matched graft which had been implanted into an anterior chamber which had an intact sympathetic nerve supply. Based on the results of these studies, investigative efforts can now be directed at studying a number of important aspects associated with the relationship between T lymphocyte ontogeny and the sympathetic nervous system.
本研究的目的是确定胸腺上皮移植物的前房植入是否可作为一种有效的体内实验模型，用于探究胸腺的交感神经支配影响胸腺细胞动力学的可能机制。我们的研究结果表明，经脱氧鸟苷处理的胸腺上皮移植物植入眼前房后，能够接纳宿主淋巴祖细胞，支持T淋巴细胞成熟过程，并能够将成熟T细胞输出到先前T细胞缺陷宿主的次级淋巴器官。此外，我们证实，从植入无交感神经输入的前房的胸腺上皮移植物中回收的淋巴细胞数量通常多于从植入有完整交感神经供应的前房的匹配移植物中回收的淋巴细胞数量。基于这些研究结果，现在可以将研究工作指向与T淋巴细胞个体发生和交感神经系统之间关系相关的一些重要方面。
