Antohi S, Antohi-Talle O
Virologie. 1987 Jan-Mar;38(1):61-70.
Molecular studies on viral oncogenes and their products have led to the discovery of physiological proto-oncogenes, involved in the control of cell proliferation and gene activation. Other genetic and molecular investigations, initiated in Drosophila melanogaster and continued in different multicellular eukaryotes, have made evident the homoeotic genes, which are directly correlated with cell specialization, in the complex processes of differentiation and morphogenesis. Both gene classes are conserved to a high extent during evolution. They are involved in the eukaryotic mechanisms of differentiation control and proto-oncogenes, in particular, are related to malignant transformation. Some available data suggest a certain extent of relatedness between the gene products of both gene classes. A differentiation trigger model, including retroviral transposition, homoeotic genes and proto-oncogenes is discussed.
对病毒癌基因及其产物的分子研究，已促成了对生理原癌基因的发现，这些原癌基因参与细胞增殖控制和基因激活。始于黑腹果蝇并在不同多细胞真核生物中持续开展的其他遗传和分子研究，已揭示了同源异型基因，它们在分化和形态发生的复杂过程中与细胞特化直接相关。这两类基因在进化过程中都高度保守。它们参与真核生物的分化控制机制，尤其是原癌基因与恶性转化有关。一些现有数据表明这两类基因的产物之间存在一定程度的相关性。本文讨论了一个包括逆转录病毒转座、同源异型基因和原癌基因的分化触发模型。
