David A S, Jeste D V, Folstein M F, Folstein S E
Acta Neurol Scand. 1987 Feb;75(2):130-9. doi: 10.1111/j.1600-0404.1987.tb07907.x.
Psychiatric patients with tardive dyskinesia (TD) may be difficult to distinguish from those with Huntington's Disease (HD), who frequently have psychiatric symptoms. This study compared 14 patients with HD with 21 patients (15 schizophrenics and 6 with affective disorder), matched for involuntary movements, using a quantitated neurological examination and other objective and semi-objective tests. The HD group was significantly more impaired on measures of voluntary movement and saccadic eye movements. When the psychiatric group was subdivided, voluntary motor impairment was most marked in schizophrenics with both TD and parkinsonism. The implications of these findings are discussed.
患有迟发性运动障碍（TD）的精神科患者可能难以与患有亨廷顿舞蹈症（HD）的患者区分开来，后者经常出现精神症状。本研究将14名HD患者与21名患者（15名精神分裂症患者和6名情感障碍患者）进行了比较，这些患者在非自主运动方面相匹配，采用定量神经学检查及其他客观和半客观测试。HD组在自主运动和眼球扫视运动测量方面的受损程度明显更严重。当将精神科组进行细分时，自主运动障碍在同时患有TD和帕金森症的精神分裂症患者中最为明显。文中讨论了这些发现的意义。
