a Department of Medical Nanotechnology, Regenerative Nanomedicine Research Group, School of Advanced Technologies in Medicine , Tehran University of Medical Sciences , Tehran , Iran.
b Medical Biomaterial Research Center (MBRC) , Tehran University of Medical Sciences , Tehran , Iran.
Artif Cells Nanomed Biotechnol. 2018 Nov;46(7):1380-1389. doi: 10.1080/21691401.2017.1369424. Epub 2017 Aug 24.
Development of next-generation bioabsorbable stents based on magnesium alloys is gaining lots of attention. However, finding an appropriate coating in order to enhance its corrosion resistance along with preserving other requirements is still a challenge. In this study, three FDA-approved polymers, namely poly(lactic acid), polycaprolactone and poly(lactic-co-glycolic acid), have been investigated as potential coatings for magnesium-based stents to enhance their corrosion resistance, biocompatibility and haemocompatibility. Potentiodynamic and electrochemical impedance spectroscopy results demonstrated that PLA and PLGA coating performed better in improving corrosion resistance in comparison with uncoated and other coated samples. Although all coated and bare samples displayed desirable results of haemocompatibility assays, PLA-coated samples showed better outcome in terms of biocompatibility. The results revealed that PLA can be considered as a potential coating material to enhance the main characteristics of magnesium-based bioabsorbable stents.
基于镁合金的下一代可生物吸收支架的发展受到了广泛关注。然而，寻找一种合适的涂层以提高其耐腐蚀性同时保持其他要求仍然是一个挑战。在这项研究中，三种已获得 FDA 批准的聚合物，即聚乳酸、聚己内酯和聚乳酸-羟基乙酸共聚物，被研究作为镁基支架的潜在涂层，以提高其耐腐蚀性、生物相容性和血液相容性。动电位和电化学阻抗谱结果表明，与未涂层和其他涂层样品相比，PLA 和 PLGA 涂层在改善耐腐蚀性方面表现更好。尽管所有涂层和未涂层样品的血液相容性试验结果都令人满意，但 PLA 涂层样品在生物相容性方面表现出更好的结果。结果表明，PLA 可以被认为是一种有潜力的涂层材料，以增强基于镁的可生物吸收支架的主要特性。
