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复合聚合物/蜡涂层作为生物可吸收镁冠状动脉支架的防腐蚀屏障。

Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents.

作者信息

Andreeva Tonya D, Walker Oliver, Rudt Alexander, Jung Ole, Barbeck Mike, Gülcher Manfred, Krastev Rumen

机构信息

Faculty "Life Sciences", Reutlingen University, Alteburgstraße 150, 72762, Reutlingen, Germany.

Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. 21, 1113, Sofia, Bulgaria.

出版信息

Heliyon. 2024 Jul 3;10(13):e34025. doi: 10.1016/j.heliyon.2024.e34025. eCollection 2024 Jul 15.

Abstract

Magnesium and its alloys are suitable materials for biodegradable biomedical implants such as cardiovascular stents. Here we introduce an innovative composite polyelectrolyte multilayer/wax coating applied to commercial coronary Mg-based stents serving as a barrier layer effectively retarding corrosion. This hydrophobic coating, build by layer-by-layer technology, appeared very thin, smooth, homogeneous, strongly adherent and completely covering the surface of the Mg-stent. degradation tests showed greater resistance to degradation of coated Mg-stents compared to uncoated and passivated ones. Cytocompatibility studies proved that Mg-stent coated with the composite coating was non-cytotoxic and improved fibroblast cell viability compared to the uncoated Mg-stent.

摘要

镁及其合金是用于可生物降解生物医学植入物(如心血管支架)的合适材料。在此,我们介绍一种应用于商用冠状动脉镁基支架的创新复合聚电解质多层/蜡涂层,它作为有效延缓腐蚀的阻挡层。这种通过逐层技术构建的疏水涂层看起来非常薄、光滑、均匀、附着力强且完全覆盖了镁支架的表面。降解测试表明,与未涂层和钝化的镁支架相比,涂层镁支架具有更强的抗降解能力。细胞相容性研究证明,与未涂层的镁支架相比,涂有复合涂层的镁支架无细胞毒性且提高了成纤维细胞的活力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56f4/11280269/79500814184f/gr1.jpg

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