Olmedo M, Merrow M, Geibel M
University of Seville, Seville, Spain.
Ludwig-Maximilians University, Munich, Germany.
Adv Genet. 2017;97:43-80. doi: 10.1016/bs.adgen.2017.05.001. Epub 2017 Jun 16.
The genetics toolkit is pretty successful in drilling down into minutiae. The big challenge is to integrate the information from this specialty as well as those of biochemistry, physiology, behavior, and anatomy to explain how fundamental biological processes really work. Sleep, the circadian clock and development all qualify as overarching processes that encompass levels from molecule to behavior as part of their known mechanisms. They overlap each other, such that understanding the mechanisms of one can lead to insights into one of the others. In this essay, we consider how the experimental approaches and findings relating to Caenorhabditis elegans development and lethargus on one hand, and to the circadian clock and sleep in higher organisms on the other, could complement and enhance one another.
遗传学工具在深入研究细节方面相当成功。最大的挑战是整合来自该专业以及生物化学、生理学、行为学和解剖学等专业的信息，以解释基本生物学过程的实际运作方式。睡眠、生物钟和发育都属于总体过程，作为其已知机制的一部分，涵盖了从分子到行为的各个层面。它们相互重叠，以至于理解其中一个的机制可以为理解其他机制之一带来启示。在本文中，我们将探讨一方面与秀丽隐杆线虫发育和蛰伏相关的实验方法及发现，另一方面与高等生物的生物钟和睡眠相关的实验方法及发现，如何相互补充和促进。
