Institute of Neurobiology, University of Lübeck, Germany.
Institute of Neurobiology, University of Lübeck, Germany.
Free Radic Biol Med. 2018 May 1;119:8-16. doi: 10.1016/j.freeradbiomed.2017.11.003. Epub 2017 Nov 10.
The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.
24 小时睡眠-觉醒周期是昼夜节律钟系统的最显著输出之一。同时，睡眠-觉醒行为的变化反馈于行为和生理昼夜节律，从而改变了身体时钟网络的协调。睡眠和昼夜节律紊乱具有相似的生理终点，包括代谢、认知和免疫功能障碍。这就提出了一个问题，即这些现象在多大程度上存在因果关系。在这篇综述中，我们总结了睡眠剥夺和睡眠时机不当的不同生理后果，并讨论了生物钟机制在这方面发挥中介作用的实验证据。
