pH Conditions under Which Pyrazinamide Works in Humans.
作者信息
Srivastava Shashikant, Pasipanodya Jotam G, Gumbo Tawanda
机构信息
Center for Infectious Diseases Research and Experimental Therapeutics, Baylor University Medical Center, Dallas, Texas, USA.
Center for Infectious Diseases Research and Experimental Therapeutics, Baylor University Medical Center, Dallas, Texas, USA
出版信息
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.00854-17. Print 2017 Sep.
Abstract
摘要
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本文引用的文献
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Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests.预测儿童结核病治疗失败和死亡的药物浓度阈值：随机森林中的面包屑踪迹
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A Long-term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies.一种用于评估婴儿药物疗效和肝毒性的长期共灌注播散性肺结核-3D肝脏中空纤维模型
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Sterilizing Activity of Pyrazinamide in Combination with First-Line Drugs in a C3HeB/FeJ Mouse Model of Tuberculosis.吡嗪酰胺与一线药物联合在C3HeB/FeJ小鼠结核病模型中的杀菌活性
Antimicrob Agents Chemother. 2015 Dec 7;60(2):1091-6. doi: 10.1128/AAC.02637-15. Print 2016 Feb.
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Pharmacokinetics-pharmacodynamics of pyrazinamide in a novel in vitro model of tuberculosis for sterilizing effect: a paradigm for faster assessment of new antituberculosis drugs.吡嗪酰胺在一种新型结核病体外杀菌模型中的药代动力学-药效学：一种快速评估新型抗结核药物的范例
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Activation of pyrazinamide and nicotinamide in acidic environments in vitro.吡嗪酰胺和烟酰胺在体外酸性环境中的活化作用。
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J Exp Med. 1966 Mar 1;123(3):445-68. doi: 10.1084/jem.123.3.445.
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Evidence that vesicles containing living, virulent Mycobacterium tuberculosis or Mycobacterium avium in cultured human macrophages are not acidic.有证据表明，在培养的人类巨噬细胞中，含有活的、有毒力的结核分枝杆菌或鸟分枝杆菌的囊泡并非呈酸性。
Infect Immun. 1991 May;59(5):1823-31. doi: 10.1128/iai.59.5.1823-1831.1991.
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