Onodera K
Arch Int Pharmacodyn Ther. 1987 Feb;285(2):263-76.
Male Wistar rats maintained on a thiamine deficient diet showed mouse-killing behavior (muricide). On the 30th day of experimental feeding, the incidence of the muricide was 70%. Intraperitoneal (i.p.) injection of 3-(3,4-dihydroxyphenyl)-l-alanine (l-dopa) suppressed the muricide in a dose-dependent manner. This suppressive effect was potentiated with carbidopa, but was quite reduced by pretreatment with alpha-monofluoromethyldopa or FLA-63. These results indicated that the effect of l-dopa was dependent on its decarboxylation, and its conversion to noradrenaline (NA) essential for muricidal suppression in the brain. The NA precursors, l-dopa, l-threo-dops or maprotiline and Y-8894, which can increase the availability of synaptic catecholamines (CA), also showed muricidal suppression. CA depletors (alpha-methyl-p-tyrosine, FLA-63 and alpha-monofluoromethyl-p-tyrosine) did not significantly increase the incidence of muricide induced by thiamine deficiency nor decrease the number of killer-rats. These findings suggest that brain CA may not participate in the mediation of muricide induced by thiamine deficiency in this experiment, but such muricide can be pharmacologically characterized by the effects which are brought about by catecholaminergic agents.
维持在硫胺素缺乏饮食的雄性Wistar大鼠表现出杀鼠行为（muricide）。在实验喂养的第30天，杀鼠行为的发生率为70%。腹腔注射3-(3,4-二羟基苯基)-L-丙氨酸（L-多巴）以剂量依赖的方式抑制了杀鼠行为。卡比多巴可增强这种抑制作用，但用α-单氟甲基多巴或FLA-63预处理后，这种抑制作用会显著降低。这些结果表明，L-多巴的作用依赖于其脱羧作用，并且其转化为去甲肾上腺素（NA）对于大脑中杀鼠抑制作用至关重要。NA前体L-多巴、L-苏式-多巴或马普替林以及Y-8894，可增加突触儿茶酚胺（CA）的可用性，也表现出杀鼠抑制作用。CA耗竭剂（α-甲基对酪氨酸、FLA-63和α-单氟甲基对酪氨酸）并未显著增加硫胺素缺乏诱导的杀鼠行为的发生率，也未减少杀鼠大鼠的数量。这些发现表明，在本实验中，脑CA可能不参与硫胺素缺乏诱导的杀鼠行为的介导，但这种杀鼠行为可以通过儿茶酚胺能药物的作用进行药理学表征。
