Abe Y, Tadano T, Yonezawa A, Kisara K
Pharmacol Biochem Behav. 1987 Jan;26(1):77-81. doi: 10.1016/0091-3057(87)90537-5.
The effects of dopamine (DA) and nomifensine (NF) on muricide activity induced by thiamine deficiency were examined. The chronic administration of L-dopa and nomifensine during feeding of thiamine deficient diet attenuated the muricide activity. Moreover, acute administration of L-dopa or nomifensine (IP) and dopamine or nomifensine (ICV) suppressed the thiamine deficiency-induced muricide activity dose-dependently. Small doses of apomorphine inhibited the muricide response significantly. The suppressive effects of dopamine and nomifensine were antagonized by pretreatment with 6-hydroxydopamine, but were not changed by pretreatment with p-chlorophenylalanine. These results suggest that the dopaminergic system has an important role in the regulation to the thiamine deficiency-induced muricide response.
研究了多巴胺（DA）和诺米芬辛（NF）对硫胺素缺乏诱导的杀鼠活性的影响。在喂食硫胺素缺乏饮食期间长期给予左旋多巴和诺米芬辛可减弱杀鼠活性。此外，急性给予左旋多巴或诺米芬辛（腹腔注射）以及多巴胺或诺米芬辛（脑室内注射）可剂量依赖性地抑制硫胺素缺乏诱导的杀鼠活性。小剂量阿扑吗啡可显著抑制杀鼠反应。多巴胺和诺米芬辛的抑制作用可被6-羟基多巴胺预处理拮抗，但不受对氯苯丙氨酸预处理的影响。这些结果表明多巴胺能系统在调节硫胺素缺乏诱导的杀鼠反应中起重要作用。
