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Dipeptidyl peptidase IV in human T lymphocytes. An approach to the role of a membrane peptidase in the immune system.

作者信息

Schön E, Eichmann E, Grunow R, Jahn S, Kiessig S T, Volk H D, Ansorge S

出版信息

Biomed Biochim Acta. 1986;45(11-12):1523-8.

PMID:2883967
Abstract

Dipeptidyl peptidase IV (DP IV), an ectoenzyme in the cell membrane of human T lymphocytes, is an important constituent in the process of lymphocyte activation and proliferation. In the presence of specific inhibitors and antibodies against DP IV several in vitro functions of activated lymphocytes were found to be impaired. These include mitogen induced DNA synthesis, immunoglobulin secretion and production of interferon-gamma. The functional importance of DP IV during activation of lymphocytes is underlined by an increase in cellular DP IV activity upon mitogenic stimulation.

摘要

相似文献

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引用本文的文献

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The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis.免疫系统和炎症性疾病（包括动脉粥样硬化）中的二肽基肽酶家族、脯氨酰寡肽酶和脯氨酰羧肽酶
Front Immunol. 2015 Aug 7;6:387. doi: 10.3389/fimmu.2015.00387. eCollection 2015.
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Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells.二肽基肽酶IV抑制剂可诱导在PWM刺激的外周血单核细胞和T细胞中转化生长因子-β1的分泌。
Immunology. 1997 Jul;91(3):354-60. doi: 10.1046/j.1365-2567.1997.d01-2258.x.
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Dipeptidyl peptidase IV--subcellular localization, activity and kinetics in lymphocytes from control subjects, immunodeficient patients and cord blood.
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Clin Exp Immunol. 1988 Nov;74(2):201-5.