Reinhold D, Bank U, Bühling F, Neubert K, Mattern T, Ulmer A J, Flad H D, Ansorge S
Department of Internal Medicine, Medical Academy of Magdeburg, Germany.
Immunobiology. 1993 Aug;188(4-5):403-14. doi: 10.1016/S0171-2985(11)80223-8.
In the present report, we describe that synthetic inhibitors of and polyclonal and monoclonal antibodies against the membrane ectoenzyme dipeptidyl peptidase IV (DP IV, CD26) inhibit the production of IL-2 and IL-6 and, concomitantly, DNA synthesis of pokeweed mitogen-stimulated peripheral blood mononuclear cells (PBMC). The release of IL-1 and TNF-alpha, was not influenced under these conditions. The data support the hypothesis that DP IV, possibly in conjunction with other peptidase, is involved in the regulation of activation and proliferation of T lymphocytes.
在本报告中，我们描述了膜外切酶二肽基肽酶IV（DP IV，CD26）的合成抑制剂以及针对该酶的多克隆和单克隆抗体，可抑制白细胞介素-2（IL-2）和白细胞介素-6的产生，并同时抑制商陆有丝分裂原刺激的外周血单个核细胞（PBMC）的DNA合成。在这些条件下，白细胞介素-1（IL-1）和肿瘤坏死因子-α（TNF-α）的释放未受影响。这些数据支持以下假说：DP IV可能与其他肽酶一起，参与T淋巴细胞激活和增殖的调节。
