Lekharaju Venkata Pawan Kumar, Iqbal Javaid, Noorullah Omar, Polavarapu Naveen, Menon Shyam, Hood Stephen, Stern Nick, Sturgess Richard
Digestive Diseases Unit, Aintree University Hospitals NHS Foundation Trust, Liverpool, UK.
Department of Gastroenterology, Newcross Hospital, The Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
Frontline Gastroenterol. 2013 Apr;4(2):138-142. doi: 10.1136/flgastro-2012-100239. Epub 2012 Nov 29.
Emergency ERCP may be required in patients with severe cholangitis who rapidly deteriorate with multi-organ dysfunction and who cannot wait until the next available elective list. A significant proportion of patients require ventilatory and inotropic support. We describe our experience on the outcome of emergency ERCP in this cohort of critically ill patients. Medical records of cases undergoing ERCP between November 2008 and November 2011 were retrospectively reviewed. Patients who were in intensive care unit or required general anaesthesia due to haemodynamic compromise at the time of ERCP were included. Total of 2237 ERCPs were performed during this period, of which 36 (2%) emergency ERCP's were performed in 33 patients. The median age was 79 years. All procedures were performed under general anaesthesia in emergency operating room. In 27/36 procedures (75%), the patients required inotropes. Indications included cholangitis (78%), pancreatitis (14%) and post-operative bile leak (8%). Biliary cannulation was achieved in 100% of cases. Endoscopic findings included CBD stones (64%), CBD stones and an additional pathology (8%), bile leak (8%), CBD stricture (5%), Mirizzi's (3%) and blocked plastic stent (3%). In 23/36 (64%) procedures a stent was inserted. In 11/36 (30%) procedures a balloon trawl was sufficient to clear the bile duct. Thirty-day mortality was 25%. Although the 30-day mortality remains high due to multi-organ failure, ERCP is successful and effective in the majority of patients and results in a good outcome for this cohort of critically ill patients, in whom the prognosis is inevitably poor without emergency biliary drainage.
对于患有严重胆管炎且迅速恶化为多器官功能障碍、无法等待下一个择期手术安排的患者,可能需要进行急诊内镜逆行胰胆管造影术(ERCP)。相当一部分患者需要通气和使用血管活性药物支持。我们描述了在这组重症患者中急诊ERCP的治疗结果。回顾性分析了2008年11月至2011年11月期间接受ERCP治疗的病例的医疗记录。纳入了在ERCP时处于重症监护病房或因血流动力学不稳定而需要全身麻醉的患者。在此期间共进行了2237例ERCP,其中33例患者进行了36例(2%)急诊ERCP。中位年龄为79岁。所有手术均在急诊手术室全身麻醉下进行。在36例手术中的27例(75%)中,患者需要使用血管活性药物。适应证包括胆管炎(78%)、胰腺炎(14%)和术后胆漏(8%)。100%的病例实现了胆管插管。内镜检查结果包括胆总管结石(64%)、胆总管结石合并其他病变(8%)、胆漏(8%)、胆总管狭窄(5%)、Mirizzi综合征(3%)和塑料支架堵塞(3%)。在36例手术中的23例(64%)中插入了支架。在36例手术中的11例(30%)中,球囊探查足以清理胆管。30天死亡率为25%。尽管由于多器官功能衰竭30天死亡率仍然很高,但ERCP在大多数患者中是成功且有效的,对于这组重症患者产生了良好的结果,而对于这些患者,如果不进行紧急胆道引流,预后必然很差。