维库溴铵、泮库溴铵、Org 6368和琥珀胆碱对麻醉家猪的神经肌肉阻滞作用比较

Comparative neuromuscular blocking effects of vecuronium, pancuronium, Org 6368 and suxamethonium in the anaesthetized domestic pig.

作者信息

Muir A W, Marshall R J

出版信息

Br J Anaesth. 1987 May;59(5):622-9. doi: 10.1093/bja/59.5.622.

DOI:10.1093/bja/59.5.622

Abstract

The neuromuscular blocking and cardiovascular effects of three competitive neuromuscular blocking drugs, vecuronium, pancuronium and Org 6368, and the depolarizing drug suxamethonium, have been evaluated in the anaesthetized domestic pig. Both the relative time-course and the order of potency of the drugs agreed well with published data in man. In addition, the cardiovascular side-effects of pancuronium and Org 6368 were identified readily. These preliminary results suggest that the pig may provide more reliable neuromuscular blocking time-course data than does the more commonly utilized cat model.

摘要

在麻醉的家猪身上评估了三种竞争性神经肌肉阻滞药物（维库溴铵、泮库溴铵和Org 6368）以及去极化药物琥珀胆碱的神经肌肉阻滞和心血管效应。这些药物的相对作用时间过程和效价顺序与已发表的人体数据非常吻合。此外，泮库溴铵和Org 6368的心血管副作用很容易被识别。这些初步结果表明，与更常用的猫模型相比，猪可能提供更可靠的神经肌肉阻滞时间过程数据。