猫卵巢颗粒细胞瘤治疗前后的血清抗苗勒管激素浓度
Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat.
作者信息
Heaps Laura A, Scudder Christopher J, Lipscomb Vicky J, Steinbach Sarah Ml, Priestnall Simon L, Martineau Henny, Szladovits Balazs, Fowkes Robert C, Garden Oliver A
机构信息
Department of Clinical Science and Services, Royal Veterinary College, North Mymms, UK.
Endocrine Signalling Group, Comparative Biomedical Sciences, Royal Veterinary College, London, UK.
出版信息
JFMS Open Rep. 2017 Aug 10;3(2):2055116917722701. doi: 10.1177/2055116917722701. eCollection 2017 Jul-Dec.
CASE SUMMARY
A 15-year-old female cat was presented for investigation of progressive behavioural changes, polyuria, polydipsia and periuria. An ovarian granulosa cell tumour was identified and the cat underwent therapeutic ovariohysterectomy (OHE). The cat's clinical signs resolved, but 6 months later it was diagnosed as having an anaplastic astrocytoma and was euthanased. Serum anti-Müllerian hormone (AMH) concentration prior to OHE was increased vs a control group of entire and neutered female cats. Following OHE, serum AMH concentration decreased to <1% of the original value.
RELEVANCE AND NOVEL INFORMATION
Serum AMH measurement may represent a novel diagnostic and monitoring tool for functional ovarian neoplasms in cats.
病例摘要
一只15岁的雌性猫因进行性行为改变、多尿、多饮和排尿困难前来检查。诊断为卵巢颗粒细胞瘤，该猫接受了治疗性卵巢子宫切除术（OHE）。猫的临床症状消失，但6个月后被诊断为间变性星形细胞瘤并实施了安乐死。与完整和绝育的雌性猫对照组相比，OHE前血清抗缪勒管激素（AMH）浓度升高。OHE后，血清AMH浓度降至原值的<1%。
相关性和新信息
血清AMH测量可能是猫功能性卵巢肿瘤的一种新的诊断和监测工具。
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