Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Neurology, Chongqing Fifth People's Hospital, Chongqing, China.
Biomed Res Int. 2017;2017:1524107. doi: 10.1155/2017/1524107. Epub 2017 Aug 3.
This study aim to determine changes of serum butyrylcholinesterase (BChE) activity in PD patients and related dementia.
Consecutive PD patients and healthy controls were included and clinical data were collected. Fast serum BChE activity was determined and compared between healthy controls and PD patients. Independent risk factors were performed for BChE activity, PD, and related dementia. The relationship between BChE activity and disease severity was also evaluated. Receiver operating characteristic (ROC) curves were obtained to explore serum BChE activity in distinguishing PD patients and related dementia.
Serum BChE activity mainly independently correlated with gender, albumin, triglyceride, body mass index, and PD. Serum BChE activity decreased in PD patients compared with healthy controls. Based on the ROC curve, the optimal cut-off point was 6864.08 IU/L for distinguishing PD patients, and the sensitivity and specificity values were 61.8% and 72.1%. It inversely correlated with Unified Parkinson's Disease Rating Scale score. BChE activity decreased in PD-related dementia compared with those without dementia. The sensitivity and specificity values were 70.6% and 76.3%, respectively, with an optimal cut-off point of 6550.00 IU/L.
Serum BChE activity can be regarded as a biomarker for PD and related dementia.
本研究旨在确定帕金森病（PD）患者及相关痴呆患者血清丁酰胆碱酯酶（BChE）活性的变化。
连续纳入 PD 患者和健康对照者并收集临床资料。快速测定血清 BChE 活性并比较健康对照组和 PD 患者之间的差异。对 BChE 活性、PD 和相关痴呆的独立危险因素进行分析。还评估了 BChE 活性与疾病严重程度之间的关系。获得受试者工作特征（ROC）曲线以探讨血清 BChE 活性在鉴别 PD 患者和相关痴呆中的作用。
血清 BChE 活性主要与性别、白蛋白、甘油三酯、体重指数和 PD 独立相关。与健康对照组相比，PD 患者的血清 BChE 活性降低。根据 ROC 曲线，区分 PD 患者的最佳截断值为 6864.08IU/L，其敏感性和特异性分别为 61.8%和 72.1%。BChE 活性与统一帕金森病评定量表评分呈负相关。与无痴呆的 PD 患者相比，PD 相关痴呆患者的 BChE 活性降低。最佳截断值为 6550.00IU/L，敏感性和特异性分别为 70.6%和 76.3%。
血清 BChE 活性可作为 PD 和相关痴呆的生物标志物。
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