着丝粒染色质的翻译后修饰

Post-translational Modifications of Centromeric Chromatin.

作者信息

García Del Arco Ana, Erhardt Sylvia

机构信息

Center for Molecular Biology of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany.

Cell Networks Excellence Cluster, Heidelberg University, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany.

出版信息

Prog Mol Subcell Biol. 2017;56:213-231. doi: 10.1007/978-3-319-58592-5_9.

DOI:10.1007/978-3-319-58592-5_9

PMID:28840239

Abstract

Regulation of chromatin structures is important for the control of DNA processes such as gene expression, and misregulation of chromatin is implicated in diverse diseases. Covalent post-translational modifications of histones are a prominent way to regulate chromatin structure and different chromatin regions bear their specific signature of histone modifications. The composition of centromeric chromatin is significantly different from other chromatin structures and mainly defined by the presence of the histone H3-variant CENP-A. Here we summarize the composition of centromeric chromatin and what we know about its differential regulation by post-translational modifications.

摘要

染色质结构的调控对于控制诸如基因表达等DNA相关过程至关重要，而染色质调控异常与多种疾病相关。组蛋白的共价翻译后修饰是调控染色质结构的一种重要方式，不同的染色质区域具有其特定的组蛋白修饰特征。着丝粒染色质的组成与其他染色质结构显著不同，主要由组蛋白H3变体CENP-A的存在所定义。在此，我们总结了着丝粒染色质的组成以及我们所知的其通过翻译后修饰进行差异调控的情况。