Center for Nuclear Medicine, Clinical Center of Serbia, University of Belgrade, Visegradska 26, Belgrade, 11000, Serbia.
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Rheumatol Int. 2018 Feb;38(2):179-187. doi: 10.1007/s00296-017-3798-y. Epub 2017 Aug 24.
The aim of this article was to critically assess the usefulness of hybrid molecular imaging (FDG PET/CT and FDG PET/MR) procedures in the evaluation of inflammatory activity in retroperitoneal fibrosis (RPF). A systematic review of the literature was performed using PubMed without timeline restriction and using the following keywords: retroperitoneal fibrosis, disease activity, diagnostic techniques, PET/CT, PET/MR. We evaluated full text articles written in the English language. Case reports, review articles or editorials and articles not in the field of interest of this review were excluded. Nine articles comprising a total of 186 patients met the inclusion criteria and were included and described in this systematic review. The new hybrid molecular imaging methods give promising results in the evaluation of the activity of the disease, quantification and prediction of therapeutic response and in tailoring medical therapy in RPF. FDG PET/CT can be a valuable tool in detecting disease activity, particularly in asymptomatic patients with RPF with acute phase reactant increase. Hybrid imaging can predict therapy response outcome and the best time for stent removal. Although PET/MR has potential advantage in small lesions and has reduced radiation exposure in comparison to PET/CT, PET quantification parameters have potentially higher diagnostic value over MR parameters in the evaluation of RPF. Acute phase reactants alone may not be reliable for the management and follow-up assessment of the disease. Hybrid imaging in RFP could be more comfortable, more accurate, with less radiation burden than different separate imaging studies acquired at different points in time.
本文旨在批判性评估 FDG PET/CT 和 FDG PET/MR 混合分子成像在评估腹膜后纤维化（RPF）炎症活动中的作用。使用无时间限制的 PubMed 进行文献系统回顾，并使用以下关键字：腹膜后纤维化、疾病活动、诊断技术、PET/CT、PET/MR。我们评估了以英文撰写的全文文章。排除病例报告、综述文章或社论以及不属于本综述兴趣领域的文章。符合纳入标准并包括在本系统评价中的共有 9 篇文章，共纳入 186 例患者。新型混合分子成像方法在评估疾病活动、定量和预测治疗反应以及定制 RPF 中的药物治疗方面提供了有希望的结果。FDG PET/CT 可作为检测疾病活动的有价值工具，特别是在 RPF 伴有急性期反应物增加的无症状患者中。混合成像可以预测治疗反应结果和支架取出的最佳时间。尽管与 PET/CT 相比，PET/MR 在小病灶中具有潜在优势，并且辐射暴露减少，但在评估 RPF 方面，PET 定量参数在诊断价值上可能优于 MR 参数。仅急性期反应物可能不足以管理和随访疾病。与不同时间点获取的不同单独成像研究相比，RFP 中的混合成像可能更舒适、更准确、辐射负担更小。
