Al-Bawardy Rasha F, Waldo Stephen W, Rosenfield Kenneth
Department of Medicine, Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA.
Department of Medicine, Division of Cardiology, VA Eastern Colorado Healthcare System, Denver, CO, USA.
Curr Cardiol Rep. 2017 Aug 24;19(10):99. doi: 10.1007/s11886-017-0913-3.
This review paper provides a summary on the use of drug-coated balloons in peripheral artery disease. It covers the main drug-coated balloon (DCB) trials. It is divided into categories of lesions: superficial femoral artery and popliteal lesions, infra-popliteal lesions and in-stent restenosis. It also includes an overview of the future of DCBs, highlighting the main ongoing trials.
The latest research on DCB focuses on newer types of DCBs, mainly paclitaxel-coated but with lower doses. Another area of latest DCB research is its use in superficial femoral artery and popliteal artery in-stent restenosis, with superior outcomes. Drug-coated balloons produce better outcomes than percutaneous transluminal angioplasty alone in de novo and in-stent restenosis lesions of superficial femoral artery and popliteal arteries. More data are needed to demonstrate efficacy and safety of DCBs in infrapopliteal disease. Newer DCBs and adjunctive therapy may provide improved outcomes for peripheral artery disease interventions.
本文综述了药物涂层球囊在周围动脉疾病中的应用。涵盖了主要的药物涂层球囊（DCB）试验。按病变类别划分：股浅动脉和腘动脉病变、腘以下病变及支架内再狭窄。还包括对DCB未来发展的概述，重点介绍了正在进行的主要试验。
DCB的最新研究集中在新型DCB上，主要是低剂量紫杉醇涂层的。DCB最新研究的另一个领域是其用于股浅动脉和腘动脉支架内再狭窄，效果更佳。在股浅动脉和腘动脉的初发及支架内再狭窄病变中，药物涂层球囊比单纯经皮腔内血管成形术产生更好的效果。需要更多数据来证明DCB在腘以下疾病中的疗效和安全性。新型DCB和辅助治疗可能会改善周围动脉疾病干预的效果。
