Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Sciences), School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, China.
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.
Sci China Life Sci. 2017 Nov;60(11):1191-1196. doi: 10.1007/s11427-017-9128-3. Epub 2017 Aug 22.
Gut microbiota play an essential role in shaping immune cell responses. The liver was continuously exposed to metabolic products of intestinal commensal bacterial through portal vein and alteration of gut commensal bateria was always associated with increased risk of liver inflammation and autoimmune disease. Considered as a unique immunological organ, the liver is enriched with a large number of innate immune cells. Herein, we summarize the available literature of gut microbiota in shaping the response of hepatic innate immune cells including NKT cells, NK cells, γδ T cells and Kupffer cells during health and disease. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of innate immune cell-related liver disease.
肠道微生物群在塑造免疫细胞反应方面发挥着重要作用。肝脏通过门静脉不断暴露于肠道共生细菌的代谢产物中，肠道共生细菌的改变总是与肝脏炎症和自身免疫性疾病的风险增加相关。肝脏被认为是一个独特的免疫器官，富含大量先天免疫细胞。本文总结了肠道微生物群在健康和疾病状态下塑造肝脏先天免疫细胞（包括 NKT 细胞、NK 细胞、γδ T 细胞和库普弗细胞）反应的相关文献，这一知识可能有助于为先天免疫细胞相关肝病的预防和治疗开发新的创新策略。
