丙型肝炎病毒与 ARF4 之间的相互作用。
Interplay between hepatitis C virus and ARF4.
机构信息
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100176, China.
Department of Emergency, 171st Hospital of PLA, Jiujiang, 332000, China.
出版信息
Virol Sin. 2017 Dec;32(6):533-536. doi: 10.1007/s12250-017-4000-0.
Abstract
In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may provide new therapeutic targets for antiviral therapy.
摘要
总之，我们在这里表明，HCV 感染与 ARF4 的上调有关，而 ARF4 可促进 HCV 的复制。在 HCV 感染时，CREB3 被重新分配到细胞核并激活 ARF4 的转录。我们的研究表明，在 HCV 复制中上调的宿主因子 ARF4，可能为抗病毒治疗提供新的治疗靶点。
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