Denis Gerald V, Sebastiani Paola, Andrieu Guillaume, Tran Anna H, Strissel Katherine J, Lombardi Frank L, Palmer Julie R
Department of Medicine, Cancer Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Obesity (Silver Spring). 2017 Nov;25(11):1916-1920. doi: 10.1002/oby.21943. Epub 2017 Aug 25.
The principal objective of this investigation was to identify novel cytokine associations with BMI and type 2 diabetes (T2D).
Cytokines were profiled from African American women with obesity who donated plasma to the Komen Tissue Bank. Multiplex bead arrays of analytes were used to quantify 88 cytokines and chemokines in association with clinical diagnoses of metabolic health. Regression models were generated after elimination of outliers.
Among women with obesity, T2D was associated with breast adipocyte hypertrophy and with six plasma analytes, including four chemokines (chemokine [C-C motif] ligand 2, chemokine [C-C motif] ligand 16, chemokine [C-X-C motif] ligand 1, and chemokine [C-X-C motif] ligand 16) and two growth factors (interleukin 2 and epidermal growth factor). In addition, three analytes were associated with obesity independently of diabetes: interleukin 4, soluble CD40 ligand, and chemokine (C-C motif) ligand 3.
Profiling of inflammatory cytokines combined with measures of BMI may produce a more personalized risk assessment for obesity-associated disease in African American women.
本研究的主要目的是确定与体重指数（BMI）和2型糖尿病（T2D）相关的新型细胞因子。
从向科门组织库捐献血浆的肥胖非裔美国女性中分析细胞因子。使用分析物多重珠阵列来量化88种细胞因子和趋化因子，并将其与代谢健康的临床诊断相关联。在剔除异常值后生成回归模型。
在肥胖女性中，T2D与乳腺脂肪细胞肥大以及六种血浆分析物相关，包括四种趋化因子（趋化因子[C-C基序]配体2、趋化因子[C-C基序]配体16、趋化因子[C-X-C基序]配体1和趋化因子[C-X-C基序]配体16）和两种生长因子（白细胞介素2和表皮生长因子）。此外，三种分析物与肥胖相关，与糖尿病无关：白细胞介素4、可溶性CD40配体和趋化因子（C-C基序）配体3。
分析炎性细胞因子并结合BMI测量可能会为非裔美国女性肥胖相关疾病产生更个性化的风险评估。
