Cross T J S, Villanueva A, Shetty S, Wilkes E, Collins P, Adair A, Jones R L, Foxton M R, Meyer T, Stern N, Warshow U, Khan N, Prince M, Khakoo S, Alexander G J, Khan S, Reeves H, Marshall Aileen, Williams R
Department of Hepatology, The Royal Liverpool Hospital, Liverpool, UK.
Institute of Liver Studies, Kings College Hospital, London, UK.
Frontline Gastroenterol. 2016 Apr;7(2):82-89. doi: 10.1136/flgastro-2015-100617. Epub 2015 Dec 7.
Hepatocellular carcinoma (HCC), the sixth most common cancer worldwide and third most common cause of cancer related death, is closely associated with the presence of cirrhosis. Survival is determined by the stage of the cancer, with asymptomatic small tumours being more amenable to treatment. Early diagnosis is dependent on regular surveillance and the primary objective of this survey was to gain a better understanding of the baseline attitudes towards and provision of ultrasound surveillance (USS) HCC surveillance in the UK. In addition, information was obtained on the stages of cancer of the patients being referred to and discussed at regional multidisciplinary team meetings.
UK hepatologists, gastroenterologists and nurse specialists were sent a questionnaire survey regarding the provision of USS for detection of HCC in their respective hospitals.
Provision of surveillance was poor overall, with many hospitals lacking the necessary mechanisms to make abnormal results, if detected, known to referring clinicians. There was also a lack of standard data collection and in many hospitals basic information on the number of patients with cirrhosis and how many were developing HCC was not known. For the majority of new HCC cases was currently being made only at an incurable late stage (60%).
In the UK, the current provision of USS based HCC surveillance is poor and needs to be upgraded urgently.
肝细胞癌(HCC)是全球第六大常见癌症,也是癌症相关死亡的第三大常见原因,与肝硬化的存在密切相关。生存率取决于癌症的阶段,无症状小肿瘤更易于治疗。早期诊断依赖于定期监测,本调查的主要目的是更好地了解英国对超声监测(USS)肝癌监测的基线态度和实施情况。此外,还获取了在地区多学科团队会议上转诊和讨论的患者的癌症阶段信息。
向英国肝病学家、胃肠病学家和护士专家发送了一份关于在各自医院提供USS以检测HCC的问卷调查。
总体监测情况较差,许多医院缺乏必要机制,无法将检测到的异常结果告知转诊的临床医生。还缺乏标准数据收集,在许多医院,肝硬化患者数量以及有多少患者正在发展为HCC的基本信息并不清楚。目前,大多数新的HCC病例仅在无法治愈的晚期才被发现(60%)。
在英国,目前基于USS的肝癌监测情况较差,急需升级。