State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology , Guangzhou 510070, P.R. China.
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, P.R. China.
Org Lett. 2017 Sep 15;19(18):4786-4789. doi: 10.1021/acs.orglett.7b02159. Epub 2017 Aug 25.
Driven by bioinspiration and appreciation of their structures, the first biomimetic total syntheses with structural revision of the acylphloroglucinols myrtucommulone J and myrtucommuacetalone, two biologically meaningful natural products, were achieved through a biosynthetic hemiacetalization/dehydration/[3 + 3]-type cycloaddition domino sequence with high step efficiency. These syntheses result in a corrected structure for myrtucommulone J.
受生物启发并欣赏其结构，通过具有高步骤效率的生物合成半缩醛化/脱水/[3+3]-型环加成级联序列，实现了具有结构修正的酰基间苯三酚醇 myrtucommulone J 和 myrtucommuacetalone 的仿生全合成，这两个生物意义重大的天然产物。这些合成导致了 myrtucommulone J 的结构修正。
