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Intrathecally administered dynorphin-(1-17) modulates morphine-induced antinociception differently in morphine-naive and morphine-tolerant rats.

作者信息

Schmauss C, Herz A

出版信息

Eur J Pharmacol. 1987 Mar 31;135(3):429-31. doi: 10.1016/0014-2999(87)90695-9.

DOI:10.1016/0014-2999(87)90695-9
PMID:2884124
Abstract

The intrathecal (i.t.) administration of morphine, but not of dynorphin-(1-17), dose dependently inhibited thermal nociceptive responses to radiant heat. In morphine-naive rats, i.t. dynorphin-(1-17) slightly antagonized morphine analgesia but potentiated it in morphine-tolerant rats. These data provide further evidence that dynorphin-(1-17) modulates the effects of exogenously administered opiates differently, depending upon whether the animals are opiate-naive or opiate-tolerant.

摘要

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