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仅有一小部分首发精神病患者是通过前驱期服务前来就诊的:一项针对英国大型心理健康项目的回顾性调查。

Only a small proportion of patients with first episode psychosis come via prodromal services: a retrospective survey of a large UK mental health programme.

作者信息

Ajnakina Olesya, Morgan Craig, Gayer-Anderson Charlotte, Oduola Sherifat, Bourque François, Bramley Sally, Williamson Jessica, MacCabe James H, Dazzan Paola, Murray Robin M, David Anthony S

机构信息

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.

Society and Mental Health Research Group, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.

出版信息

BMC Psychiatry. 2017 Aug 25;17(1):308. doi: 10.1186/s12888-017-1468-y.

Abstract

BACKGROUND

Little is known about patients with a first episode of psychosis (FEP) who had first presented to prodromal services with an "at risk mental state" (ARMS) before making the transition to psychosis. We set out to identify the proportion of patients with a FEP who had first presented to prodromal services in the ARMS state, and to compare these FEP patients with FEP patients who did not have prior contact with prodromal services.

METHODS

In this study information on 338 patients aged ≤37 years who presented to mental health services between 2010 and 2012 with a FEP was examined. The data on pathways to care, clinical and socio-demographic characteristics were extracted from the Biomedical Research Council Case Register for the South London and Maudsley NHS Trust.

RESULTS

Over 2 years, 14 (4.1% of n = 338) young adults presented with FEP and had been seen previously by the prodromal services. These ARMS patients were more likely to enter their pathway to psychiatric care via referral from General Practice, be born in the UK and to have had an insidious mode of illness onset than FEP patients without prior contact with the prodromal services.

CONCLUSIONS

In the current pathways to care configuration, prodromal services are likely to prevent only a few at-risk individuals from transitioning to psychosis even if effective preventative treatments become available.

摘要

背景

对于首次发作精神病(FEP)患者,在其转变为精神病之前首次以“处于精神病风险状态”(ARMS)就诊于前驱期服务机构的情况,人们了解甚少。我们旨在确定以ARMS状态首次就诊于前驱期服务机构的FEP患者的比例,并将这些FEP患者与未与前驱期服务机构有过接触的FEP患者进行比较。

方法

在本研究中,对2010年至2012年间因FEP就诊于心理健康服务机构的338名年龄≤37岁患者的信息进行了检查。从南伦敦和莫兹利国民保健服务信托基金的生物医学研究理事会病例登记册中提取了护理途径、临床和社会人口学特征的数据。

结果

在两年时间里,14名(占338名的4.1%)年轻人首次发作精神病,且此前曾就诊于前驱期服务机构。与未与前驱期服务机构有过接触的FEP患者相比,这些处于ARMS状态的患者更有可能通过全科医生转诊进入精神科护理途径,在英国出生,且发病方式隐匿。

结论

在当前的护理途径配置中,即使有有效的预防性治疗方法,前驱期服务机构可能也只能防止少数有风险的个体转变为精神病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ac/5574213/a95e75bfdc3e/12888_2017_1468_Fig1_HTML.jpg

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