Research Unit for Dietary Studies at the Parker Institute, Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Nordre Fasanvej 57, entrance 5, ground floor, 2000, Frederiksberg, Denmark.
Department of Clinical Epidemiology (Formerly 'Institute of Preventive Medicine'), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark.
Nutr J. 2017 Aug 25;16(1):51. doi: 10.1186/s12937-017-0274-1.
Studies have suggested a link between alcohol intake and adiposity. However, results from longitudinal studies have been inconsistent, and a possible interaction with genetic predisposition to adiposity measures has often not been taken into account.
To examine the association between alcohol intake recorded at baseline and subsequent annual changes in body weight (∆BW), waist circumference (ΔWC) and WC adjusted for BMI (ΔWC), and to test for interaction with genetic predisposition scores based on single nucleotide polymorphisms (SNPs) associated with various forms of adiposity.
This study included a total of 7028 adult men and women from MONICA, the Diet, Cancer and Health cohort (DCH), and the Inter99 studies. We combined 50 adiposity-associated SNPs into four scores indicating genetic predisposition to BMI, WC, WHR and all three traits combined. Linear regression was used to examine the association of alcohol intake (drinks of 12 g (g) alcohol/day) with ΔBW, ΔWC, and ΔWC and to examine possible interactions with SNP-scores. Results from the analyses of the individual cohorts were combined in meta-analyses.
Each additional drink/day was associated with a ΔBW/year of -18.0 g (95% confidence interval (CI): -33.4, -2.6, P = 0.02) and a ΔWC of -0.3 mm/year (-0.5, -0.0, P = 0.03). In analyses of women only, alcohol intake was associated with a higher ΔWC of 0.5 mm/year (0.2, 0.9, P = 0.002) per drink/day. Overall, we found no statistically significant interactions between the four SNP-scores and alcohol intake in relation to changes in adiposity measures. However in analyses of women separately, we found interaction between the complete score of all 50 SNPs and alcohol intake in relation to ΔBW (P for interaction = 0.03). No significant interaction was observed among the men.
Alcohol intake was associated with a decrease in BW and WC among men and women, and an increase in WC among women only We found no strong indication that these associations depend on a genetic predisposition to adiposity.
Registry: ClinicalTrials.gov Trial number: CT00289237 , Registered: 19 September 2005 retrospectively registered.
研究表明饮酒与肥胖之间存在关联。然而，纵向研究的结果并不一致，并且通常没有考虑到遗传易感性对肥胖指标的可能影响。
研究基线时饮酒量与随后的体重年度变化（ΔBW）、腰围年度变化（ΔWC）以及体重指数调整后的腰围年度变化（ΔWC）之间的关系，并检验与基于与各种形式肥胖相关的单核苷酸多态性（SNP）的遗传易感性得分的交互作用。
本研究共纳入了来自 MONICA、饮食、癌症和健康队列（DCH）和 Inter99 研究的 7028 名成年男女。我们将 50 个与肥胖相关的 SNP 组合成四个评分，分别表示 BMI、WC、腰臀比和这三种特征的综合遗传易感性评分。线性回归用于检验饮酒量（12g 酒精/天）与 ΔBW、ΔWC 和 ΔWC 的关系，并检验与 SNP 评分的可能交互作用。对来自各个队列的分析结果进行了荟萃分析。
每天多喝一杯酒与 BW 每年减少 18.0g（95%置信区间：-33.4，-2.6，P=0.02）和 WC 每年减少 0.3mm（-0.5，-0.0，P=0.03）相关。仅在女性分析中，饮酒量与腰围每年增加 0.5mm（0.2，0.9，P=0.002）相关。总体而言，我们未发现 SNP 评分与饮酒量在与肥胖指标变化相关方面存在统计学显著的交互作用。然而，在对女性进行单独分析时，我们发现了 50 个 SNP 完整评分与饮酒量在与 ΔBW 相关方面的交互作用（交互作用 P 值=0.03）。在男性中未观察到显著的交互作用。
饮酒量与男性和女性的 BW 和 WC 减少有关，与女性的 WC 增加有关。我们没有强有力的证据表明这些关联取决于肥胖的遗传易感性。
ClinicalTrials.gov 注册号：CT00289237，注册日期：2005 年 9 月 19 日，回顾性注册。
Zotero 插件