The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Obesity (Silver Spring). 2014 Mar;22(3):901-8. doi: 10.1002/oby.20540. Epub 2013 Aug 19.
Genome-wide association studies have identified genetic variants associating with BMI, however, it is un-clarified whether the same variants also influence body weight fluctuations.
Among 3,982 adult individuals that attended both a baseline and a five-year follow-up examination in the Danish Inter99 intervention study, a genetic risk score (GRS) was constructed based on 30 BMI variants to address whether it is associated with body weight changes. Moreover, it was examined whether the effect of lifestyle changes was modulated by the GRS.
The GRS associated strongly with baseline body weight, with a per risk allele increase of 0.45 (0.33-0.58) kg (P = 2.7 × 10(-12) ), corresponding to a body weight difference of 3.41 (2.21-4.60) kg comparing the highest (≥ 30 risk alleles) and lowest (≤ 26 risk alleles) risk allele tertile. No association was observed with changes in body weight during the five years. Changes in lifestyle, including physical activity, diet and smoking habits associated strongly with body weight changes, however, no interactions with the GRS was observed.
The GRS associated with body weight cross-sectionally, but not with changes over a five-year period. Body weight changes were influenced by lifestyle changes, however, independently of the GRS.
全基因组关联研究已经确定了与 BMI 相关的遗传变异，但尚不清楚相同的变异是否也会影响体重波动。
在丹麦 Inter99 干预研究中，3982 名成年人参加了基线和五年随访检查，根据 30 个 BMI 变异构建了遗传风险评分（GRS），以确定其是否与体重变化有关。此外，还研究了 GRS 是否调节了生活方式变化的效果。
GRS 与基线体重密切相关，每个风险等位基因增加 0.45（0.33-0.58）kg（P = 2.7 × 10(-12)），最高（≥ 30 个风险等位基因）和最低（≤ 26 个风险等位基因）风险等位基因三分位组之间的体重差异为 3.41（2.21-4.60）kg。在五年期间，体重没有变化。生活方式的改变，包括体力活动、饮食和吸烟习惯，与体重变化密切相关，但与 GRS 没有相互作用。
GRS 与体重呈横断面相关，但与五年期间的体重变化无关。体重变化受生活方式变化的影响，但与 GRS 无关。
