Department of Otorhinolaryngology head and neck surgery, Chinese PLA General Hospital, Beijing, 100083, China.
Department of Otorhinolaryngology, The Affiliated Hospital of The Medical School of Ningbo University, Ningbo, 315020, China.
Sci Rep. 2017 Aug 25;7(1):9479. doi: 10.1038/s41598-017-08375-2.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly heterogeneous disease with different host defence responses. However, whether periostin and vascular endothelial growth factor (VEGF) are similarly impaired in patients with eosinophilic CRSwNP (ENP) and those with non-eosinophilic CRSwNP (nENP) remains unclear. We sought to evaluate the expression and possible modulation of periostin and VEGF, regulated on activation normal T expressed and secreted (RANTES) and eotaxin-2 in the polyp tissues from 30 patients with ENP and from 36 patients with nENP and in middle turbinate tissues from 12 control subjects. We found that ENP tissues exhibited a significantly increased expression of periostin and VEGF compared with tissues from patients with nENP and control subjects (P < 0.05, respectively). Accordingly, the expression of VEGF, RANTES, and eotaxin-2 in ENP fibroblasts was significantly up-regulated after stimulation with up-regulated periostin in vitro, but the expression of VEGF and RANTES was significantly inhibited by stimulation with down-regulated periostin. Our findings suggest that periostin might play an important role in the occurrence and progression of ENP and might be a potential therapeutic target.
伴有鼻息肉的慢性鼻-鼻窦炎（CRSwNP）是一种具有高度异质性的疾病，具有不同的宿主防御反应。然而，骨膜蛋白和血管内皮生长因子（VEGF）在嗜酸性 CRSwNP（ENP）患者和非嗜酸性 CRSwNP（nENP）患者中是否同样受损尚不清楚。我们试图评估 30 例 ENP 患者和 36 例 nENP 患者的息肉组织以及 12 例对照患者的中鼻甲组织中骨膜蛋白和 VEGF、激活正常 T 表达和分泌的调节因子（RANTES）和嗜酸粒细胞趋化因子-2 的表达及其可能的调节作用。我们发现，与 nENP 患者和对照组患者的组织相比，ENP 组织中骨膜蛋白和 VEGF 的表达明显增加（P<0.05）。相应地，体外上调骨膜蛋白可显著上调 ENP 成纤维细胞中 VEGF、RANTES 和嗜酸粒细胞趋化因子-2 的表达，但下调骨膜蛋白可显著抑制 VEGF 和 RANTES 的表达。我们的研究结果表明，骨膜蛋白可能在 ENP 的发生和发展中起重要作用，可能是一个潜在的治疗靶点。
