Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Germany.
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Operative and Preventive Dentistry, Germany.
J Craniomaxillofac Surg. 2017 Oct;45(10):1724-1730. doi: 10.1016/j.jcms.2017.07.008. Epub 2017 Jul 27.
Compromised wound healing in cranio-maxillo-facial surgery is a threat to the patient's rehabilitation. Therapy of chronic and/or infected wounds is time- and cost-consuming, burdensome and occasionally futile. Cold atmospheric plasma is a new approach that promises to overcome these limitations. The aim of this proof-of-concept study was to evaluate the clinical outcome of cold plasma irradiation in patients with impaired wound healing who are refractory to conservative wound therapy and/or revision surgery.
We enrolled six patients (mean age: 63.5 years; SD 8.8 years; 1 female and 5 males) who experienced various cranio-maxillo-facial surgical procedures and suffered from wound healing disturbances. In addition to established wound care, all wounds were irradiated with cold atmospheric plasma. The primary outcome variable was the attainment of complete wound closure.
In all patients, complete remission in terms of wound closure was observed within a mean time of 15.5 weeks (range: 4-38 weeks). No undesirable side effects were observed, and no inflammation or infection occurred after cold plasma initiation.
The use of cold atmospheric plasma might offer a reliable, conservative treatment option in complicated wound healing disturbances in cranio-maxillo-facial surgery.
颅面外科中伤口愈合受损会威胁到患者的康复。慢性和/或感染性伤口的治疗既耗时又费钱，且繁琐，有时还徒劳无益。冷等离体技术是一种新方法，有望克服这些局限性。本概念验证研究的目的是评估冷等离子体照射对保守伤口治疗和/或修正手术无效的愈合受损患者的临床疗效。
我们纳入了 6 名（平均年龄：63.5 岁；标准差 8.8 岁；1 名女性，5 名男性）经历了各种颅面外科手术并出现伤口愈合障碍的患者。除了标准的伤口护理外，所有伤口均采用冷等离体照射。主要结局变量为完全伤口闭合。
所有患者的伤口均在平均 15.5 周（范围：4-38 周）内完全闭合。在冷等离子体治疗开始后，未观察到不良副作用，也未发生炎症或感染。
冷等离体的使用可能为颅面外科中复杂的伤口愈合障碍提供一种可靠的保守治疗选择。
