Department of Basic Medical Sciences, School of Medicine, Center for Life Sciences, Tsinghua University, Beijing 100084, China.
Department of Basic Medical Sciences, School of Medicine, Center for Life Sciences, Tsinghua University, Beijing 100084, China.
Curr Opin Genet Dev. 2017 Oct;46:170-178. doi: 10.1016/j.gde.2017.07.009. Epub 2017 Aug 19.
Pervasive transcription in mammalian genomes produces thousands of long noncoding RNA (lncRNA) transcripts. Although they have been implicated in diverse biological processes, the functional relevance of most lncRNAs remains unknown. Recent studies reveal the prevalence of lncRNA-mediated cis regulation on nearby transcription. In this review, we summarize cis- and trans-acting lncRNAs involved in stem cell pluripotency and reprogramming, highlighting the role of regulatory lncRNAs in providing an additional layer of complexity to the regulation of genes that govern cell fate during development.
哺乳动物基因组中的普遍转录产生了数千种长非编码 RNA（lncRNA）转录本。尽管它们已被牵涉到多种生物学过程中，但大多数 lncRNA 的功能相关性仍然未知。最近的研究揭示了 lncRNA 介导的顺式调控在附近转录中的普遍性。在这篇综述中，我们总结了参与干细胞多能性和重编程的顺式和反式作用 lncRNA，强调了调节性 lncRNA 在为发育过程中控制细胞命运的基因调控提供额外复杂性方面的作用。
