肥胖症中的脂肪组织炎症：代谢反应还是免疫反应？

Adipose tissue inflammation in obesity: a metabolic or immune response?

机构信息

Division of Diabetes, Endocrinology and Metabolism, Hammersmith Campus, Imperial College London, London, UK.

出版信息

Curr Opin Pharmacol. 2017 Dec;37:35-40. doi: 10.1016/j.coph.2017.08.006. Epub 2017 Aug 24.

DOI:10.1016/j.coph.2017.08.006

Abstract

Adipose tissue is not only a reservoir for energy, but also an immune organ. In the context of obesity, the development of insulin resistance is now recognised to be initiated by inflammation of the adipose tissue. However, the primary events triggering this inflammation are still unclear, as a complex combination of endocrine and immune factors act to regulate this adipose tissue microenvironment. Below we discuss the different factors involved and how they affect the biology of the adipose tissue in obesity.

摘要

脂肪组织不仅是能量的储存库，也是一个免疫器官。在肥胖的背景下，人们现在已经认识到胰岛素抵抗的发展是由脂肪组织的炎症引起的。然而，引发这种炎症的主要事件仍不清楚，因为内分泌和免疫因素的复杂组合作用于调节脂肪组织的微环境。下面我们将讨论涉及到的不同因素以及它们如何影响肥胖症中脂肪组织的生物学特性。