Kimura Naoya, Hiraki Masatsugu, Furukawa Shunsuke, Okuyama Keiichiro, Kohya Naohiko, Sakai Masashi, Kawaguchi Atsushi, Ikubo Akashi, Samejima Ryuichiro
Department of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Saga 847-8588, Japan.
Education and Research Center for Community Medicine, Saga University Faculty of Medicine, Saga, Saga 849-8501, Japan.
Mol Clin Oncol. 2024 Oct 1;21(6):89. doi: 10.3892/mco.2024.2787. eCollection 2024 Dec.
The present study investigated the risk factors for recurrence in patients with stage II-III colorectal cancer (CRC) who underwent colorectal surgery. Data from 232 patients with stage II and III CRC who underwent primary tumor resection were retrospectively analyzed. Univariate and multivariate analyses were performed to determine the risk factors for recurrence. The overall recurrence rate was 21.6% (n=50/232). Univariate Cox regression analysis identified diabetes mellitus (DM) (P=0.032) as a risk factor for recurrence. In addition, multivariate Cox regression analysis showed that DM was an independent risk factor for recurrence-free survival (RFS) (hazard ratio 2.40, P=0.016). The RFS curve obtained using the Kaplan-Meier method indicated that in patients with stage III colon cancer, the non-DM group demonstrated a significantly longer RFS than the DM group (P=0.012). In conclusion, the present study demonstrated that DM may be an independent risk factor for recurrence in patients undergoing curative resection for stage III CRC. Consequently, better postoperative therapy and careful monitoring might be required, especially in patients with stage III CRC and preoperative DM.
本研究调查了接受结直肠手术的II-III期结直肠癌（CRC）患者复发的危险因素。对232例接受原发性肿瘤切除的II期和III期CRC患者的数据进行了回顾性分析。进行单因素和多因素分析以确定复发的危险因素。总体复发率为21.6%（n=50/232）。单因素Cox回归分析确定糖尿病（DM）（P=0.032）为复发的危险因素。此外，多因素Cox回归分析表明，DM是无复发生存（RFS）的独立危险因素（风险比2.40，P=0.016）。使用Kaplan-Meier方法获得的RFS曲线表明，在III期结肠癌患者中，非DM组的RFS明显长于DM组（P=0.012）。总之，本研究表明，DM可能是接受III期CRC根治性切除患者复发的独立危险因素。因此，可能需要更好的术后治疗和仔细监测，尤其是在III期CRC和术前DM患者中。
