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腹腔镜袖状胃切除术治疗糖尿病 - 5 年结果。

Laparoscopic sleeve gastrectomy for diabetics - 5-year outcomes.

机构信息

Division of General Surgery, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Division of General Surgery, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.

出版信息

Surg Obes Relat Dis. 2017 Oct;13(10):1658-1663. doi: 10.1016/j.soard.2017.06.009. Epub 2017 Jul 18.

Abstract

OBJECTIVE

Although the laparoscopic sleeve gastrectomy (SG) is increasingly performed for morbid obesity, gastric bypass is still considered by many to be the gold standard procedure for obese diabetic patients. The aim of this study was to assess the long-term results of SG in morbidly obese patients with type 2 diabetes.

METHODS

Diabetic patients who underwent SG at a single center between 2009 and 2011 were included. Outcomes assessed included postoperative complications, weight loss, and resolution or improvement in co-morbidities with an emphasis on diabetes, including glycated hemoglobin (HbA1C) and medication status.

RESULTS

Fifty-one diabetic patients underwent SG, 35 females and 16 males, with a collective mean age of 49 years and a mean body mass index of 43.2 kg/m. On average, patients had had diabetes for 5.4 ± 7.3 years before surgery. Mean HbA1C and fasting glucose levels were 7.9 ± 1.6% and 166.9 ± 63 mg/dL, respectively. Eleven patients (22%) were insulin dependent at the time of surgery. Average body mass index at a mean follow-up of 5 years after surgery was 34.4 ± 5.8 kg/m, with an average HbA1C of 6.6 ± 1% and an average fasting glucose of 123 ± 60 mg/dL. Only 3 patients remained insulin dependent.

CONCLUSION

SG offers retainable weight loss results, accompanied by longstanding resolution or improvement of diabetes. Prospective, randomized controlled studies are warranted to better compare long-term outcomes between SG and gastric bypass.

摘要

目的

尽管腹腔镜袖状胃切除术(SG)越来越多地用于治疗病态肥胖症,但许多人仍认为胃旁路术是肥胖糖尿病患者的金标准手术。本研究旨在评估 SG 治疗病态肥胖症合并 2 型糖尿病患者的长期疗效。

方法

本研究纳入了 2009 年至 2011 年间在一家中心接受 SG 的糖尿病患者。评估的结果包括术后并发症、体重减轻以及合并症(重点是糖尿病)的缓解或改善,包括糖化血红蛋白(HbA1C)和药物治疗情况。

结果

51 例糖尿病患者接受了 SG 治疗,其中 35 例为女性,16 例为男性,平均年龄为 49 岁,平均体重指数为 43.2kg/m²。平均而言,患者在手术前患有糖尿病 5.4±7.3 年。平均 HbA1C 和空腹血糖水平分别为 7.9±1.6%和 166.9±63mg/dL。11 例(22%)患者在手术时依赖胰岛素。术后平均 5 年随访时的平均体重指数为 34.4±5.8kg/m²,平均 HbA1C 为 6.6±1%,平均空腹血糖为 123±60mg/dL。仅 3 例患者仍依赖胰岛素。

结论

SG 可获得可维持的减重效果,并长期缓解或改善糖尿病。需要前瞻性、随机对照研究来更好地比较 SG 和胃旁路术之间的长期结果。

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