Banc Ana, Stan Cristina, Florian Ioan Stefan
Department of Ophthalmology, Iuliu Hatieganu University of Medicine and Pharmacy, Clinicilor Street no 3-5, 400006, Cluj-Napoca, Romania.
Ophthalmology Clinic, Emergency County Hospital Cluj, Cluj-Napoca, Romania.
Childs Nerv Syst. 2018 Jan;34(1):51-60. doi: 10.1007/s00381-017-3578-8. Epub 2017 Aug 26.
Optic pathway gliomas (OPG) represent an important cause of visual loss in pediatric population. The indication of treatment is based on clinical or neuroimaging progression. Visual acuity loss is the most important symptom of disease progression, but children with OPG are frequently unable to complete the testing of visual function. Optical coherence tomography (OCT) was suggested as an objective tool for visual assessment. A literature review was performed in order to determine the role of retinal OCT as a surrogate marker of vision in children with OPG.
The search was performed using PubMed, Embase, and Web of Science databases and was restricted to articles published in English between 2000 and 2016, with a minimum of ten participants enrolled.
Eleven studies met the eligibility criteria and were included in the present review. Both neurofibromatosis-1 associated and sporadic OPG were investigated.
Retinal OCT is a promising tool to be considered as a screening or follow-up test in children with OPG, and further multicenter research is encouraged.
视路胶质瘤（OPG）是儿童视力丧失的重要原因。治疗指征基于临床或神经影像学进展。视力丧失是疾病进展的最重要症状，但患有OPG的儿童常常无法完成视觉功能测试。光学相干断层扫描（OCT）被认为是一种用于视觉评估的客观工具。进行了一项文献综述，以确定视网膜OCT作为OPG患儿视力替代指标的作用。
使用PubMed、Embase和Web of Science数据库进行检索，检索范围限于2000年至2016年间发表的英文文章，纳入研究的参与者至少有10名。
11项研究符合纳入标准并被纳入本综述。研究对象包括与1型神经纤维瘤病相关的OPG和散发性OPG。
视网膜OCT是一种有前景的工具，可考虑用于OPG患儿的筛查或随访测试，鼓励开展进一步的多中心研究。
