Huang Xiaobo, Zhang Bingchuan, Xu Hui
Research Institute of Pesticidal Design & Synthesis, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China.
Research Institute of Pesticidal Design & Synthesis, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi Province, China.
Bioorg Med Chem Lett. 2017 Sep 15;27(18):4336-4340. doi: 10.1016/j.bmcl.2017.08.031. Epub 2017 Aug 16.
To develop natural-product-based pesticidal agents, a series of monosaccharide-related ester derivatives (17a-q and 18a-f), glucose (xylose)-piperic acid/piperic acid-like conjugates, were synthesized. Three-dimensional structures of compounds 17b, 17g, 17h, and 17n were unambiguously determined by single-crystal X-ray diffraction. Especially compounds 18e and 18f exhibited the most potent insecticidal and acaricidal activities against Mythimna separata and Tetranychus cinnabarinus. Their structure-activity relationships were also discussed.
为了开发基于天然产物的杀虫剂，合成了一系列与单糖相关的酯衍生物（17a-q和18a-f），即葡萄糖（木糖）-胡椒酸/类胡椒酸共轭物。通过单晶X射线衍射明确确定了化合物17b、17g、17h和17n的三维结构。特别是化合物18e和18f对粘虫和朱砂叶螨表现出最强的杀虫和杀螨活性。还讨论了它们的构效关系。
