Yang Ruige, Zhang Yuanyuan, Xu Hui
Research Institute of Pesticidal Design & Synthesis, College of Chemistry and Pharmacy/Crop Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China.
Research Institute of Pesticidal Design & Synthesis, College of Chemistry and Pharmacy/Crop Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China; Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling 712100, Shaanxi Province, China.
Bioorg Med Chem Lett. 2018 May 1;28(8):1410-1416. doi: 10.1016/j.bmcl.2018.02.018. Epub 2018 Feb 10.
In continuation of our program aimed at the development of natural product-based pesticidal agents, a series of isoxazoline-containing podophyllotoxin/2'(2',6')-(di)halogenopodophyllotoxin derivatives were prepared, and their structures were well characterized by H NMR, IR, optical rotation, HRMS and mp. Especially the structure of compound Ia was further confirmed by H-H COSY and NOESY spectrum. Among them, two compounds showed good insecticidal and acaricidal activities against Mythimna separata and Tetranychus cinnabarinus. Their structure-activity relationships were also observed.
作为我们旨在开发基于天然产物的杀虫剂的计划的延续，我们制备了一系列含异恶唑啉的鬼臼毒素/2'(2',6')-(二)卤代鬼臼毒素衍生物，并通过核磁共振氢谱、红外光谱、旋光度、高分辨质谱和熔点对其结构进行了充分表征。特别是化合物Ia的结构通过氢-氢化学位移相关谱和核Overhauser效应光谱进一步得到证实。其中，两种化合物对粘虫和朱砂叶螨表现出良好的杀虫和杀螨活性。我们还观察了它们的构效关系。
