Sowa Joanna E, Ślusarczyk Joanna, Trojan Ewa, Chamera Katarzyna, Leśkiewicz Monika, Regulska Magdalena, Kotarska Katarzyna, Basta-Kaim Agnieszka
Institute of Pharmacology, Polish Academy of Sciences, Department of Physiology, 12 Smętna St, 31-343 Krakow, Poland; Institute of Pharmacology, Polish Academy of Sciences, Department of Experimental Neuroendocrinology, 12 Smętna St, 31-343 Krakow, Poland.
Institute of Pharmacology, Polish Academy of Sciences, Department of Experimental Neuroendocrinology, 12 Smętna St, 31-343 Krakow, Poland.
J Neuroimmunol. 2017 Oct 15;311:79-87. doi: 10.1016/j.jneuroim.2017.08.006. Epub 2017 Aug 19.
CXCL12/SDF-1α and CX3CL1/fractalkine are constitutively expressed in the brain, which indicates their significant functions. Emerging evidence highlights the role of astrocytes and the immune system in the pathophysiology of stress-related disorders. The aim of this study was to assess whether prenatal stress affects chemokine signaling, cell viability/activation, and the iNOS pathway in astroglial cultures. Our results showed that prenatal stress lowered astrocyte viability and simultaneously increased GFAP expression. Furthermore, CX3CL1 production and the CXCL12/CXCR4-7 axis were also altered by prenatal stress. Taken together, malfunctions caused by prenatal stress may adversely influence brain development, leading to long-term effects on adult brain function and behavior.
CXCL12/SDF-1α和CX3CL1/趋化因子在大脑中持续表达，这表明它们具有重要功能。新出现的证据突出了星形胶质细胞和免疫系统在应激相关疾病病理生理学中的作用。本研究的目的是评估产前应激是否会影响星形胶质细胞培养物中的趋化因子信号传导、细胞活力/激活以及诱导型一氧化氮合酶（iNOS）途径。我们的结果表明，产前应激降低了星形胶质细胞的活力，同时增加了胶质纤维酸性蛋白（GFAP）的表达。此外，产前应激还改变了CX3CL1的产生以及CXCL12/CXCR4-7轴。综上所述，产前应激引起的功能障碍可能会对大脑发育产生不利影响，从而对成年大脑功能和行为产生长期影响。
