Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland.
Department of Biophysical Microstructures, Institute of Nuclear Physics, Polish Academy of Sciences, 31342, Kraków, Poland.
Pharmacol Rep. 2021 Dec;73(6):1626-1641. doi: 10.1007/s43440-021-00315-2. Epub 2021 Aug 14.
Nervous system diseases are the subject of intensive research due to their association with high mortality rates and their potential to cause irreversible disability. Most studies focus on targeting the biological factors related to disease pathogenesis, e.g. use of recombinant activator of plasminogen in the treatment of stroke. Nevertheless, multiple diseases such as Parkinson's disease and Alzheimer's disease still lack successful treatment. Recently, evidence has indicated that physical factors such as the mechanical properties of cells and tissue and topography play a crucial role in homeostasis as well as disease progression. This review aims to depict these factors' roles in the progression of nervous system diseases and consequently discusses the possibility of new therapeutic approaches. The literature is reviewed to provide a deeper understanding of the roles played by physical factors in nervous system disease development to aid in the design of promising new treatment approaches.
神经系统疾病由于其与高死亡率相关，并可能导致不可逆转的残疾，因此成为了密集研究的课题。大多数研究都集中在针对与疾病发病机制相关的生物因素上，例如使用重组纤溶酶原激活剂治疗中风。然而，仍有多种疾病（如帕金森病和阿尔茨海默病）缺乏有效的治疗方法。最近，有证据表明，物理因素（如细胞和组织的机械特性和形貌）在维持体内平衡和疾病进展中起着至关重要的作用。本综述旨在描述这些因素在神经系统疾病进展中的作用，并讨论新的治疗方法的可能性。通过文献回顾，深入了解物理因素在神经系统疾病发展中的作用，以帮助设计有前途的新治疗方法。
