常用可压缩性方程表征多种粉末塑性的适用性。
The suitability of common compressibility equations for characterizing plasticity of diverse powders.
机构信息
Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, United States.
Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, United States.
出版信息
Int J Pharm. 2017 Oct 30;532(1):124-130. doi: 10.1016/j.ijpharm.2017.08.096. Epub 2017 Aug 24.
The analysis of powder compressibility data yields useful information for characterizing compaction behavior and mechanical properties of powders, especially plasticity. Among the many compressibility equations proposed in powder compaction research, the Heckel equation and the Kawakita equation are the most commonly used, despite their known limitations. Systematic evaluation of the performance in analyzing compressibility data suggested the Kuentz-Leuenberger equation is superior to both the Heckel equation and the Kawakita equation for characterizing plasticity of powders exhibiting a wide range of mechanical properties.
粉末压缩性数据的分析可为粉末的压缩行为和力学性能（尤其是塑性）提供有用的信息。在粉末压缩研究中提出的众多压缩性方程中，尽管 Heckel 方程和川北方程存在已知的局限性，但它们仍然是最常用的。对分析压缩性数据的性能进行系统评估表明，对于具有广泛力学性能的粉末，Kuentz-Leuenberger 方程在描述其塑性方面优于 Heckel 方程和川北方程。
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