Vreeman Gerrit, Sun Changquan Calvin
Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, United States.
Int J Pharm X. 2021 Aug 14;3:100094. doi: 10.1016/j.ijpx.2021.100094. eCollection 2021 Dec.
Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner.
尽管能够以节省材料且快速的方式表征粉末的可塑性，但模内赫克尔分析因其对多种因素（如颗粒弹性变形、模具尺寸、润滑和速度）敏感而受到广泛批评。使用具有广泛机械性能的材料，我们表明模内 与从模外赫克尔分析、昆茨 - 洛伊恩贝格尔分析和宏观压痕获得的三个既定可塑性参数密切相关。因此，模内 是一种以节省材料且快速的方式量化粉末可塑性的可靠参数。
